ABSTRACT
Background: COVID-19 is a novel coronavirus disease caused by the severe acute respiratory syndrome coronavirus 2. Chronic kidney disease (CKD) is associated with an increased risk of both inpatient and outpatient pneumonia. Objective: To describe the effect of COVID-19 virus on patients with kidney disease and renal transplants and analyse the outcomes of patients at the time of the study. Patients and Method: This is a descriptive study conducted in Baghdad Medical City, Al Shifa Center (single centre study). The study included 13 RTPCR-positive patients who were screened in the inpatient and outpatient departments. All patients received treatment according to the Iraq Ministry of Health protocol with dose adjusted as per the glomerular filtration rate (GFR). Result: The mean age of participants was 51.46 years with males more than females. Among the positive cases, 2 had acute kidney injury (15.4%), 3 had chronic kidney diseases (23.1%), 5 had end-stage renal disease (38.5%), and 3 had had renal transplants (23.1%). 6 patients out of 13 were diabetic, 11 were hypertensive, and 1 patient had heart failure. 7 (53.8%) patients were given conservative treatment, 4 were given isolated conventional haemodialysis, and only 2 patients were kept in an intensive care unit on continuous renal replacement therapy. 2 male patients died during the treatment. Conclusion: Chronic kidney disease is a risk factor for COVID-19 infection and more mortality and infection were found in male patients as compared to female patients in our study. © 2022: Author(s).
ABSTRACT
This paper examines the biological approach used to synthesize gold nanoparticles (AuNPs) by using Myrtus communis leaves extract as reducing agent and Chloroauric acid as precursors. Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) used in addition to UV-visible spectroscopy (UV) in order to characterize the AuNPs. The biosynthesized AuNPs exhibited inhibitory effects on ferritin and lactate dehydrogenase activity in sera of covid-19 patients and the sera of healthy control subjects;the inhibition percentage with LDH was 76.86% and 63% for patient and control group, respectively. While for ferritin activity, it was 85.85% for patient group and 75.18% for control group. Kinetic studies of ferritin and lactate dehydrogenase performed. Further studies on other biological activities were required to exploit AuNPs full potential. The goal of this study is to synthesized gold nanoparticles using simple, cheap and environmentally green method. This stage is more suited to large-scale manufacturing since it is speedy and removes the complex steps in other bio based methods (by using fungi and bacteria).
ABSTRACT
The present work investigates the synthesis of silver nanoparticles by biological method using Myrtus communis leaves extract and silver nitrate as precursors. Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR) were used in addition to UV-visible spectroscopy (UV) in order to characterize the AgNPs. The biosynthesized AgNPs exhibited inhibitory effects on ferritin and lactate dehydrogenase activity in sera of covid-19 patients compared with control subjects. Kinetic studies of ferritin and lactate dehydrogenase were performed. Further studies on other biological activities were required to exploit AgNPs full potential. Conclusion of this study is prepared using simple, cheap and environmentally green method to synthesis silver nanoparticles. This stage is more suited to large-scale manufacturing since it is speedy and removes the complex steps in other biobased methods (by using fungi and bacteria). © 2022 National Information and Documentation Center (NIDOC).